09. Legido
نویسندگان
چکیده
Bone metabolism changes in patients with inflammatory bowel disease (IBD) awoke a growing interest in the past few years mostly because of their high prevalence, with estimations around 40-50% for osteopenia and 530% regarding osteoporosis (1-3). The presence of bone metabolism changes in these patients is an issue of great clinical relevance given an increased risk for bone fracture, primarily in the dorso-lumbar spine (4,5). Aims of this review include: a) an evaluation of the significance of bone metabolism changes in the setting of extradigestive manifestations in ulcerative colitis (UC) and Crohn’s disease (CD); b) an analysis of the various risk factors present in these patients –in addition to those well known by the general population, other factors inherent to this disease, mainly derived from corticoid use and BDI-related malabsorption, should be considered; c) an assessment of the role of hip and lumbar spine densitometry (DXA), as well as of the various biochemical parameters for bone resorption and formation than have been postulated as markers for bone metabolism changes in BDI, and whose role for screening and diagnostic purposes has been deemed likely; and d) a discussion of the various prevention strategies for osteoporosis and osteopenia, as well as of therapeutic options according to clinical findings, in order to provide a better multidisciplinary, integral management for IBD.
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